Quantitative Viral Serology
Recent studies have shown that the false negative rate (a negative test result for a patient with COVID-19) range from 2% to as high as 37%. If the virus testing is performed after 8-10 days from the onset of symptoms, a dramatic drop-off in positivity (a positive test result) is observed and false negative rates increase dramatically (see figure1 below).



















MLO: Stanley J. Naides, MD, FAP, FACRMaite Sabalza, Ph.D.Iswariya Venkataraman, PhD Jun 24th, 2020

IgG and IgM antibodies (part of our body's immune system) can be detected in COVID-19 as early as the first week of illness onset. Optimally, IgG and IgM antibody to specific COVID-19 markers (see COVID-19 structure below) should be performed after 2 weeks from onset of symptoms so that levels are easily measured. The presence of antibody indicates the patient has been infected. (Note: there are instances when a patient has been infected but does not produce detectable antibodies). These tests represent a tool to for the physician to confirm whether the initial negative virus test was truly negative or a false negative (an infected patient testing negative).
2-Confirming whether a negative COVID-19 test is a true negative
Allermetrix antibody testing involves IgG and IgM that is directed against the N-protein (nucleocapsid), S1-protein (spike subcomponent) and the RBD (receptor binding domain)
figure 1